Performance of an automatic quantitative ultrasound analysis of the fetal lung to predict fetal lung maturity - 21/11/12
Résumé |
Objective |
The objective of the study was to evaluate the performance of automatic quantitative ultrasound analysis (AQUA) texture extractor to predict fetal lung maturity tests in amniotic fluid.
Study Design |
Singleton pregnancies (24.0-41.0 weeks) undergoing amniocentesis to assess fetal lung maturity (TDx fetal lung maturity assay [FLM]) were included. A manual-delineated box was placed in the lung area of a 4-chamber view of the fetal thorax. AQUA transformed the information into a set of descriptors. Genetic algorithms extracted the most relevant descriptors and then created and validated a model that could distinguish between mature or immature fetal lungs using TDx-FLM as a reference.
Results |
Gestational age at enrollment was (mean [SD]) 32.2 (4.5) weeks. According to the TDx-FLM results, 41 samples were mature and 62 were not. The imaging biomarker based on AQUA presented a sensitivity 95.1%, specificity 85.7%, and an accuracy 90.3% to predict a mature or immature lung.
Conclusion |
Fetal lung ultrasound textures extracted by AQUA provided robust features to predict TDx-FLM results.
Le texte complet de cet article est disponible en PDF.Key words : fetal lung maturity, pregnancy, quantitative ultrasound
Plan
| T.C. was supported by a Río Hortega Grant from the Instituto de Salud Carlos III in Spain (CM09/00213). Financial support to E.B.-C. and Transmural Biotech SL was provided by the Comissionat per a Universitat i Recerca del Departament d'Innovació, Universitats i Empreses de la Generalitat de Catalunya. This project was also supported by The People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme FP7 under REA Grant Agreement no. 217911 (u-Volumes). |
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| Transmural Biotech has collaborative research agreements with the Hospital Clinic for the joint development and potential exploitation of imaging biomarkers. However, Transmural Biotech did not provide funding for this study. |
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| The authors report no conflict of interest. |
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| Reprints not available from the authors. |
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| Cite this article as: Palacio M, Cobo T, Martínez-Terrón M, et al. Performance of an automatic quantitative ultrasound analysis of the fetal lung to predict fetal lung maturity. Am J Obstet Gynecol 2012;207:504.e1-5. |
Vol 207 - N° 6
P. 504.e1-504.e5 - décembre 2012 Retour au numéro
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