Copeptin: a marker for stress reaction in fetuses with intrauterine growth restriction - 21/11/12
Résumé |
Objective |
To compare venous cord plasma concentrations of 4 vasoactive peptide precursors: carboxy-terminal proarginine vasopressin, CT-prondothelin (ET)-1, midregional proadrenomedullin, and MR-proatrial natriuretic peptide, between fetuses with intrauterine growth restriction and appropriate for gestational age controls.
Study Design |
Matched-pair analysis of 12 fetuses with significant intrauterine growth restriction and 42 healthy appropriate for gestational age control fetuses. All infants were singletons, delivered by elective section after 34 weeks and without chromosomal abnormalities.
Results |
Umbilical cord plasma copeptin levels (median [range]) were 4-fold higher in intrauterine growth restriction infants than in matched appropriate for gestational age controls: 23.2 (6.7–449) vs 5.1 (2.5–53) pmol/L (P < .001). Multivariate regression analysis revealed an association between copeptin and umbilical artery resistance index z-score (P = .034). The 3 other precursor peptides showed no changes.
Conclusion |
High copeptin concentrations in the cord blood of intrauterine growth restriction newborns reflect a fetal stress response and support the fetal programming hypothesis.
Le texte complet de cet article est disponible en PDF.Key words : arginine vasopressin, copeptin, intrauterine growth restriction, vasoactive peptide
Plan
| S.W. was supported by a Swiss National Science Foundation Career Award for Medical Scientists (33CM30-124101). |
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| The authors report no conflict of interest. |
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| The first 2 authors contributed equally to this study. |
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| Reprints are not available from the authors. |
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| Cite this article as: Burkhardt T, Schwabe S, Morgenthaler NG, et al. Copeptin: a marker for stress reaction in fetuses with intrauterine growth restriction. Am J Obstet Gynecol 2012;207:497.e1-5. |
Vol 207 - N° 6
P. 497.e1-497.e5 - décembre 2012 Retour au numéro
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