Effects of increased fetuin-A in human trophoblast cells and associated pregnancy outcomes - 21/11/12
Résumé |
Objective |
The purpose of this study was to determine whether fetuin-A affects trophoblast viability and invasion, whether growth factors that bind receptors that activate tyrosine kinase are impaired by fetuin-A, and whether elevated maternal serum fetuin-A levels are associated with adverse pregnancy outcomes.
Study Design |
We studied viability and invasion in first-trimester extravillous trophoblast cells that were exposed to fetuin-A, insulin-like growth factor, and placental growth factor. Insulin receptor substrates expression was assessed. We compared serum fetuin-A levels in 111 preeclampsia cases and 95 controls.
Results |
Fetuin-A reduced extravillous trophoblast cell viability and invasion in the presence or absence of growth factors. Fetuin-A reduced insulin receptor substrate–1 and tyrosine phosphorylated insulin receptor substrate–1 expression in extravillous trophoblast cells that had been treated with insulin-like growth factor. Elevated serum fetuin-A levels were more prevalent in preeclampsia cases than control subjects, even after we controlled for diabetes mellitus, hypertension, and obesity.
Conclusion |
Fetuin-A may decrease trophoblast viability and invasion caused by the inhibition of receptor tyrosine kinase activity. Elevated serum levels of fetuin-A may be associated with preeclampsia.
Le texte complet de cet article est disponible en PDF.Key words : cell culture, extravillous trophoblast, fetuin-A, preeclampsia
Plan
| Supported by a Maternal-Fetal Medicine Fellowship Training Program grant and by a University of Pennsylvania Research Foundation Grant. |
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| The authors report no conflict of interest. |
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| Reprints not available from the authors. |
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| Cite this article as: Gomez LM, Anton L, Srinivas SK, et al. Effects of increased fetuin-A in human trophoblast cells and associated pregnancy outcomes. Am J Obstet Gynecol 2012;207:484.e1-8. |
Vol 207 - N° 6
P. 484.e1-484.e8 - décembre 2012 Retour au numéro
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