Duration of membrane rupture and risk of perinatal transmission of HIV-1 in the era of combination antiretroviral therapy - 21/11/12
, Kathleen F. Brookfield, MD, Lunthita M. Duthely, MS, Victor H. Gonzalez Quintero, MD, JoNell E. Potter, PhD, Mary J. O'Sullivan, MD
Reprints: Amanda M. Cotter, MD, Department of Obstetrics and Gynecology, University of Limerick, Limerick, IrelandRésumé |
Objective |
The objective of the study was to determine whether the duration of membrane rupture of 4 or more hours is a significant risk factor for perinatal transmission of human immunodeficiency virus (HIV) in the era of combination antiretroviral therapy (ART).
Study Design |
This was a prospective cohort study of 717 HIV-infected pregnant women-infant pairs with a delivery viral load available who received prenatal care and delivered at our institution during the interval 1996-2008.
Results |
The cohort comprised 707 women receiving ART who delivered during this interval. The perinatal transmission rate was 1% in women with membranes ruptured for less than 4 hours and 1.9% when ruptured for 4 or more hours. For 493 women with a delivery viral load less than 1000 copies/mL receiving combination ART in pregnancy, there were no cases of perinatal transmission identified up to 25 hours of membrane rupture. Logistic regression demonstrated only a viral load above 10,000 copies/mL as an independent risk factor for perinatal transmission.
Conclusion |
Duration of membrane rupture of 4 or more hours is not a risk factor for perinatal transmission of HIV in women with a viral load less than 1000 copies/mL receiving combination ART.
Le texte complet de cet article est disponible en PDF.Key words : antiretroviral therapy, duration of membrane rupture, perinatal transmission, pregnancy
Plan
| A.M.C. is now at the Department of Obstetrics and Gynecology, University of Limerick, Limerick, Ireland. |
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| The authors report no conflict of interest. |
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| Cite this article as: Cotter AM, Brookfield KF, Duthely LM, et al. Duration of membrane rupture and risk of perinatal transmission of HIV-1 in the era of combination antiretroviral therapy. Am J Obstet Gynecol 2012;207:482.e1-5. |
Vol 207 - N° 6
P. 482.e1-482.e5 - décembre 2012 Retour au numéro
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