Multivariate analysis of prognostic factors in patients with rapidly progressive alopecia areata - 14/11/12
, Chizu Egusa, Ayako Hobo, MD, Ryokichi Irisawa, MD, Masashi Yamazaki, MD, PhD, Ryoji Tsuboi, MD, PhD
Reprint requests: Masaki Uchiyama, MD, Department of Dermatology, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.Abstract |
Background |
Alopecia areata (AA) is a common acquired hair disorder showing variable hair loss. Although various prognostic factors have been reported, no evident factors for determining prognosis and appropriate treatment are known.
Objective |
To identify prognostic factors in AA patients, especially those with positive results for the hair-pull test on the first visit or with a history of rapidly progressive AA (RPAA) within 6 months prior to the first visit.
Methods |
One thousand thirty (1030) patients diagnosed with AA at Tokyo Medical University Hospital were retrospectively examined for 3 years, and their prognosis was assessed on the basis of various indices using multivariate analysis.
Results |
Patients with regenerated vellus hairs showed a significantly higher improvement or cure rate regardless of severity. Early onset and lengthy duration were significantly associated with lower cure, and higher relapse, rates. RPAA patients tended to show a good prognosis regardless of the treatment employed.
Limitations |
The present study is retrospective, and treatment modalities were chosen according to clinical and social circumstances.
Conclusion |
RPAA patients tend to show a favorable prognosis regardless of treatment modality. Furthermore, the presence of regenerated vellus hairs may indicate a good prognosis.
Le texte complet de cet article est disponible en PDF.Key words : acute diffuse and total alopecia, alopecia areata, hair-pull test, multivariate analysis, prognostic factor, rapidly progressive alopecia areata
Abbreviations used : AA, ADTA, AT, AU
Plan
| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 67 - N° 6
P. 1163-1173 - décembre 2012 Retour au numéro
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