Photosensitivity disorders in children : Part II - 14/11/12

Doi : 10.1016/j.jaad.2012.07.032

Rattanavalai Chantorn, MD ^a, Henry W. Lim, MD ^b, Tor A. Shwayder, MD ^b,^⁎
^a Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
^b Department of Dermatology, Henry Ford Hospital, Detroit, Michigan

Reprint requests: Tor A. Shwayder, MD, FAAP, FAAD, Director, Pediatric Dermatology, Henry Ford Hospital, 3031 W Grand Blvd, Ste 800, Detroit, MI 48202.

Abstract

Photosensitivity disorders in children encompass a diverse group of diseases. Some inherited disorders manifest with photosensitivity early in life. Specific extracutaneous association may be the clue to diagnosis in this group of pediatric photodermatoses. Part II of this 2-part review covers hereditary photodermatoses caused by defects in nucleotide excision repair, double strand break repair, or localized or systemic biochemical abnormalities. Diagnosis and management of photoaggravated dermatoses are also discussed. Sun protection strategies are required in all patients with evidence of photosensitivity. Early recognition and prompt diagnosis is essential to minimize the long-term complications associated with inadequate photoprotection.

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Key words : children, double-strand break DNA repair, hereditary, nucleotide excision repair, photoaggravated, photodermatoses, photosensitivity, phototesting

Abbreviations used : AD, BS, COFS, CS, DD, DSBR, IMP, JDM, KS, LE, MED, NER, NLE, RTS, SLE, SLOS, TTD, UV, UV(S)S, XP