Randomized clinical trial of lovastatin in HIV-infected, HAART naïve patients (NCT00721305) - 11/11/12
Summary |
Background |
Evidence suggests that statins may modify the immune response against HIV. The aim was to evaluate the antiretroviral and immunomodulatory effects of lovastatin in HIV-infected patients, naïve for antiretroviral therapy.
Methods |
Randomized, double-blinded, placebo-controlled, phase-II clinical trial. Primary outcomes were plasma viral load and circulating CD4+ T cell count, after 6 and 12 months of treatment; secondary outcomes were CD8+ T cell count, expression of activation markers (CD38 and HLA-DR) on T cells, and clinical outcomes. With a power of 90% to detect both a decrease of 0.3 log10 in plasma HIV-1 RNA copies and an increase of 20% in the CD4+ T cell count, we estimated a required sample size of 110 HIV-infected patients (55 per group). The results were analyzed by a model of repeated measurements using Generalized Estimating Equations.
Results |
Patients were randomized to receive either lovastatin (n = 55) or placebo (n = 57). During the 12-month follow-up, there was no effect of lovastatin either on viral load (estimated average change = 0.157 copies/mL; CI 95% = −0.099 to 0.414), or on the CD4+ T cell count (estimated average change = −26.1 cells/μL; CI 95% = −89.8 to 37.6). Moreover, there were no significant differences in secondary outcomes.
Conclusions |
Daily administration of lovastatin (40 mg) for one year in HIV-infected patients, naïve for antiretroviral therapy, had no significant effect on HIV replication, the CD4+ T cell count, or the activation level of T cells.
(www.clinicaltrials.gov; ID NCT00721305).
Le texte complet de cet article est disponible en PDF.Keywords : HIV infection, Anti-HIV agents, Statin, Lovastatin, Randomized controlled trial
Plan
Vol 65 - N° 6
P. 549-558 - décembre 2012 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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