In vitro anticancer and anti-angiogenic effects of thymoquinone in mouse neuroblastoma cells (Neuro-2a) - 09/11/12
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Thymoquinone (TQ), the active constituent of Nigella sativa has exhibited cytotoxic effects in several cancer cell lines. TQ has shown promising anti-carcinogenic and anti-tumor activities through different mechanisms. We have recently shown anti-angiogenic activity of TQ via the down-regulation of vascular endothelial growth factor (VEGF) using zebrafish (Danio rerio) model. In the present study, we investigated the cytotoxicity and anti-angiogenic effects of TQ in mouse neuroblastoma cells (Neuro-2a). We found that TQ exerted strong cytotoxic effect in Neuro-2a cells. Furthermore, TQ significantly decreased the protein contents of VEGF in Neuro-2a cells, indicating its anti-angiogenic efficacy. These results support the anti-angiogenic activity of TQ and a powerful contributor to its anticancer properties. Further studies are required to investigate the use of TQ as an anticancer drug.
Le texte complet de cet article est disponible en PDF.Keywords : Neuroblastoma, Angiogenesis, Nigella sativa, Thymoquinone, VEGF
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Vol 2 - N° 4
P. 283-286 - octobre 2012 Retour au numéro
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