Pharmacology and placental transport of 17-hydroxyprogesterone caproate in singleton gestation - 30/10/12
Eunice Kennedy Shriver National Institute of Child Health and Human Development Obstetrical-Fetal Pharmacology Research Units Network
Résumé |
Objective |
The purpose of this study was to estimate pharmacokinetic parameters and to evaluate placental transport of 17-hydroxyprogesterone caproate (17-OHPC) in singleton gestation.
Study Design |
Sixty-one women who received weekly injections of 17-OHPC underwent 2 pharmacokinetic studies at 20 + 0 to 24 + 6 weeks' gestation (study 1) and 31 + 0 to 34 + 6 weeks' gestation (study 2); daily blood samples were obtained between injections. In 18 women, blood samples were obtained over a 28-day period beyond the last injection (extended study). Maternal and/or cord blood were obtained at delivery.
Results |
The half-life (median ± SD) of 17-OHPC was 16.2 ± 6 days. Concentrations of 17-OHPC were higher during study 2 than during study 1. Body mass index affected maternal 17-OHPC concentrations. Cord:maternal 17-OHPC concentration ratios averaged 0.2; 17-OHPC was detectible in cord plasma 44 days after the last maternal injection.
Conclusion |
The apparent half-life of 17-OHPC is long, and pharmacokinetic parameters vary widely between subjects and are affected by maternal body mass index. The drug crosses the placental barrier.
Le texte complet de cet article est disponible en PDF.Key words : cord blood, pharmacokinetics, placenta, preterm birth
Plan
Supported by the Obstetric Fetal Pharmacology Research Units Network of the Eunice Kennedy Shriver National Institute of Child Health and Human Development through cooperative agreements U10HD047905, U10HD047892, U10HD047892, and U10HD047892 with additional support by 1 UL1RR031975. |
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The content is solely the responsibility of the authors and does not necessarily represent the official views of the Eunice Kennedy Shriver National Institute of Child Health and Human Development or the National Institutes of Health. |
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The authors report no conflict of interest. |
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Reprints not available from the authors. |
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Cite this article as: Caritis SN, Sharma S, Venkataramanan R, et al. Pharmacology and placental transport of 17-hydroxyprogesterone caproate in singleton gestation. Am J Obstet Gynecol 2012;207:398.e1-8. |
Vol 207 - N° 5
P. 398.e1-398.e8 - novembre 2012 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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