Relationship between 17-hydroxyprogesterone caproate concentrations and gestational age at delivery in twin gestation - 30/10/12
Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
Résumé |
Objective |
We sought to evaluate in women with twin gestation the relationship between 17-hydroxyprogesterone caproate (17-OHPC) concentration and gestational age at delivery and select biomarkers of potential pathways of drug action.
Study Design |
Blood was obtained between 24-28 weeks (epoch 1) and 32-35 weeks (epoch 2) in 217 women with twin gestation receiving 17-OHPC or placebo. Gestational age at delivery and concentrations of 17-OHPC, 17-hydroxyprogesterone, progesterone, C-reactive protein (CRP), and corticotrophin-releasing hormone were assessed.
Results |
Women with higher concentrations of 17-OHPC delivered at earlier gestational ages than women with lower concentrations (P < .001). Women receiving 17-OHPC demonstrated significantly higher (P = .005) concentrations of CRP in epoch 1 than women receiving placebo but CRP values were similar in epoch 2 in both groups. A highly significant (P < .0001) positive relationship was observed between 17-OHPC concentration and progesterone and 17-hydroxyprogesterone concentrations at both epochs. Corticotropin-releasing hormone concentrations did not differ by treatment group.
Conclusion |
17-OHPC may adversely impact gestational age at delivery in women with twin gestation.
Le texte complet de cet article est disponible en PDF.Key words : 17-hydroxyprogesterone caproate, pharmacodynamics, twin gestation
Plan
The remaining members of the network are listed in the Acknowledgments. |
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The project described was supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (HD27869, HD21410, HD40512, HD34136, HD34208, HD40485, HD27915, HD40544, HD40560, HD27917, HD40500, HD34116, HD40545, HD27860, HD3680) and does not necessarily represent the official views of the NICHD or the National Institutes of Health. |
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The authors report no conflict of interest. |
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Reprints not available from the authors. |
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Cite this article as: Caritis SN, Simhan HN, Zhao Y, et al. Relationship between 17-hydroxyprogesterone caproate concentrations and gestational age at delivery in twin gestation. Am J Obstet Gynecol 2012;207:396.e1-8. |
Vol 207 - N° 5
P. 396.e1-396.e8 - novembre 2012 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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