Beyond cervical length: emerging technologies for assessing the pregnant cervix - 30/10/12
Résumé |
Spontaneous preterm birth is a heterogeneous phenotype. A multitude of pathophysiologic pathways culminate in the final common denominator of cervical softening, shortening, and dilation that leads to preterm birth. A precise description of specific microstructural changes to the cervix is imperative if we are to identify the causative upstream molecular processes and resultant biomechanical events that are associated with each unique pathway. Currently, however, we have no reliable clinical tools for quantitative and objective evaluation, which likely contributes to the reason the singleton spontaneous preterm birth rate has not changed appreciably in >100 years. Fortunately, promising techniques to evaluate tissue hydration, collagen structure, and/or tissue elasticity are emerging. These will add to the body of knowledge about the cervix and facilitate the coordination of molecular studies and ultimately lead to novel approaches to preterm birth prediction and, finally, prevention.
Le texte complet de cet article est disponible en PDF.Key words : microstructural assessment, preterm birth, quantitative ultrasound measurement, short cervix
Plan
Supported in part by National Institutes of Health grants R21HD061896 and R21HD063031 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (H.F.; T.J.H.). |
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The authors report no conflict of interest. |
Vol 207 - N° 5
P. 345-354 - novembre 2012 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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