Long-term Results of Two Prospective Bladder-sparing Trimodality Approaches for Invasive Bladder Cancer: Neoadjuvant Chemotherapy and Concurrent Radio-chemotherapy - 30/10/12
, Carmen Martin De Vidales a, Ramon Arellano b, Yamile Ibañez a, Gloria Bocardo b, Mar Perez c, Mariano Rabadan b, Feliciano García Vicente d, Jose A. Cruz Conde a, Carlos Olivier b
Reprint requests: Almudena Zapatero, M.D., Ph.D., Department of Radiation Oncology, Hospital Universitario de la Princesa, IIS-IP, Diego de León 62, 28006 Madrid, SpainRésumé |
Objective |
To report long-term outcomes of selective organ preservation for muscle-invasive bladder cancer (MIBC) using 2 bladder-sparing trimodality approaches.
Materials And Methods |
From 1990 to 2010, 80 patients with T2-T4 bladder cancer were prospectively enrolled in 2 successive bladder-sparing protocols. Forty-one patients were treated with neoadjuvant methotrexate, cisplatin, and vinblastine (MCV) chemotherapy followed by radiotherapy (60 Gy) in complete responders (protocol 1 [P1]) and 39 patients were treated with weekly cisplatin concurrent with radiotherapy (64.8 Gy) (protocol 2 [P2]).
Results |
The median follow-up was 72 months (range, 9-204 months). Five and 10-year cumulative overall survival for all series were 73% and 60% and the corresponding numbers for cancer-specific survival were 82% and 80%, respectively. Of all surviving patients, 83% maintained their own bladder. Although there were no significant differences in overall survival (P = .820), cancer-specific survival (P = .688) and distant metastasis (P = .417) between protocols, complete response rates (P = .003), and disease-free survival (P = .031) were significantly higher in P2 treatment.
Conclusion |
Trimodality therapy with bladder preservation represents a real alternative to radical cystectomy (RC) in selected patients. Overall survival and cancer-specific survival rates are encouraging with more than 80% of survivors retaining functional bladders.
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| Financial Disclosure: The authors declare that they have no relevant financial interests. |
Vol 80 - N° 5
P. 1056-1062 - novembre 2012 Retour au numéro
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