Is Statin Use Associated with Reduced Mortality After Pneumonia? A Systematic Review and Meta-analysis - 23/10/12
, Mary A.M. Rogers, PhD a, Michael Buist, BA a, Sushant Govindan, MD a, Peter K. Lindenauer, MD, MSc b, Sanjay Saint, MD, MPH a, c, Scott A. Flanders, MD a
Requests for reprints should be addressed to Vineet Chopra, MD, MSc, Department of Internal Medicine, Division of General Internal Medicine, University of Michigan Health System, 300 N. Ingalls St, Room 7C-17, Ann Arbor, MI 48109-5429Abstract |
Objective |
The objective of this study was to perform a systematic review and meta-analysis of the effects of statins on mortality following pneumonia.
Methods |
We searched MEDLINE, EMBASE, BIOSIS, Cochrane CENTRAL Register of Controlled Trials, Cambridge Scientific Abstracts, BIOSIS, and Scopus. Studies were included if they involved: participants ≥18 years of age; patients with community-acquired pneumonia; current statin users; and reported overall or adjusted mortality after pneumonia.
Results |
Of 491 citations identified, 13 studies involving 254,950 patients met eligibility criteria. Pooled unadjusted data showed that statin use was associated with lower mortality after pneumonia (odds ratio [OR] 0.62, 95% confidence interval [CI], 0.54-0.71). Pooling of adjusted data also showed reduced mortality after pneumonia (OR 0.66, 95% CI, 0.55-0.79). However, this effect was attenuated in subgroup analysis by confounders and in prospective studies.
Conclusions |
Although statin use is associated with decreased mortality after pneumonia, this effect weakens in important subgroups. Only a randomized controlled study can fully explore the link between statins and pneumonia mortality.
Le texte complet de cet article est disponible en PDF.Keywords : Inflammation, Mortality, Outcomes, Pneumonia, Statins
Plan
| Funding: None. |
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| Conflict of Interest: None. |
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| Authorship: All authors had access to the data, participated in the conception, design, writing, editing, and final approval of the manuscript. |
Vol 125 - N° 11
P. 1111-1123 - novembre 2012 Retour au numéro
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