Different biological significance of sCD14 and LPS in HIV-infection: Importance of the immunovirology stage and association with HIV-disease progression markers - 09/10/12
, Ezequiel Ruiz-Mateos a, ⁎, e 
Corresponding authors. Immunovirology Laboratory (Lab 211) of the Institute of Biomedicine of Seville (IBIS). Virgen del Rocío University Hospital, Avda. Manuel Siurot s/n, CP 41013 Seville, Spain. Tel.: +34 955 923 107; fax: +34 955 013 292.Summary |
Objectives |
Bacterial lipopolysaccharide (LPS) and soluble CD14 (sCD14) levels have been indistinctly used to measure bacterial translocation independently of the immunovirological stage in HIV infection; however, when the association of both markers with different HIV-progression end-points has been studied, discrepant results have been reported. The aim of this study was to assess the relationship between LPS and sCD14 in different HIV-infection immune stages and to determine the relationship between these biomarkers with established HIV-disease-progression-related markers, as T-cell immune activation, high-sensitivity C-reactive protein and D-dimer.
Methods |
Seventy-three chronically HIV-1-infected patients with detectable HIV-1 RNA levels were analyzed. LPS levels by use of limulus lysate assay, sCD14, intestinal fatty acid binding protein and inflammation–coagulation-associated biomarkers were assessed.
Results |
In this study, we found that LPS and sCD14 levels were only associated when low CD4+ T-cell levels and high HIV RNA levels were present. In addition, only sCD14 levels, but not LPS, were independently associated with HIV-disease progression-related markers, supporting the clinical importance of sCD14.
Conclusions |
These results indicate that LPS and sCD14 have a different biological significance and should not be indistinctly used without taking the HIV immunovirological stage into account.
Le texte complet de cet article est disponible en PDF.Keywords : Bacterial lipopolysaccharide, Bacterial translocation, Chronic immune activation, D-dimer, High-sensitivity C-reactive protein, HIV-progression, Soluble CD14
Plan
Vol 65 - N° 5
P. 431-438 - novembre 2012 Retour au numéro
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