Efficient and suitable preparation of N-sulfonyl-1,2,3,4-tetrahydroisoquinolines and ring analogues using recyclable H6P2W18O62·24H2O/SiO2 catalyst - 17/09/12
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Abstract |
Silica gel-supported H6P2W18O62·24H2O is an efficient and recyclable catalyst for the synthesis of biologically important molecules. Several substituted N-sulfonyl-1,2,3,4-tetrahydroisoquinolines and ring analogues can be prepared in very good yields and purity by direct reaction of N-aralkylsulfonamides and sym-trioxane by a Pictet-Spengler reaction in the presence of a catalytic amount of silica gel-supported H6P2W18O62·24H2O. Reactions were performed in a low volume of toluene, at 70°C and for a short time, typically 15 to 30min. The title heterocyclic compounds were prepared in very good yields (60%–95%) using the described procedure results in a clean and useful alternative, which has the advantages of a greener methodology with operative simplicity, use of a reusable and non-corrosive solid catalyst, soft reaction conditions, low reaction times, and good yields.
Le texte complet de cet article est disponible en PDF.Keywords : Silica-supported Wells-Dawson catalyst, Pictet-Spengler reaction, N-sulfonyl-1,2,3,4-tetrahydroisoquinolines and ring analogues, Heterogeneous catalysis, Recyclable catalyst
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Vol 15 - N° 9
P. 758-763 - septembre 2012 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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