Leptin and HER-2 are associated with gastric cancer progression and prognosis of patients - 12/09/12
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Abstract |
We conducted this study to evaluate the expression of leptin and its receptor, OB-Rb in gastric cancer and their relationship to clinicopathological features, VEGF and HER-2 expression, as well as the prognostic value. One hundred and ten gastric cancer specimens were detected for leptin, OB-Rb, VEGF and HER-2 by immunohistochemistry (IHC), and 96 specimens of normal gastric mucosa served as the control. The expression level of leptin, OB-Rb and HER-2 in gastric tissues were significantly higher than normal tissues (49.1% vs. 34.0%, 60.9% vs. 46.0%, 19.1% vs. 8.0%, P<0.05). There was a correlation between the expression of leptin and HER-2, both of which were significantly associated with invasion depth, lymph node metastasis, AJCC stage and VEGF expression. However, there was no correlation between OB-Rb expression and all clinicopathological features. Cox regression analyses showed that age, tumor size, histological grade, serosa invasion, AJCC stage, chemotherapy, leptin and HER-2 overexpression were prognostic factors. The survival of patients with leptin positive expression was significantly poorer than those with negative expression (OS: 20.0months vs. 32.5months, FPS: 12.0months vs. 18.0months, P<0.01). Leptin, rather than OB-Rb, played an important role in the progression and angiogenesis of gastric cancer, and was a prognostic factor for poor outcome.
Le texte complet de cet article est disponible en PDF.Keywords : Leptin, HER-2, Gastric cancer, Vascular endothelial growth factor, Immunohistochemistry
Abbreviations : CACs, EGFR, ERK, HER-2, IGF-1, IHC, JAK, MMPs, NR, OB-R, OS, PFS, PI3K, STAT, AJCC, VEGF
Plan
Vol 66 - N° 6
P. 419-424 - septembre 2012 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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