Anti-mitochondrial-2 antibodies (anti-PDC-E2): A marker for autoimmune hepatitis of children? - 08/09/12
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Summary |
In an 8-year-old boy with biochemical hepatic disorders, an histological examination of a liver biopsy showed a severe chronic hepatitis without cirrhosis. The biliary tract was normal and no toxic or infectious etiologies were found. Spontaneous improvement of the clinical status was observed in the following weeks but biochemical abnormalities were persistent and a second episode occurred 3years after. Immunological studies showed anti-mitochondrial-2 antibodies (AMA-2) confirmed by an immunoblot performed with rat mitochondrial proteins resolved by two-dimensional electrophoresis. We described here the second case in the literature of paediatric autoimmune hepatitis associated with well documented AMA-2.
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Vol 36 - N° 4
P. e57-e59 - août 2012 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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