How to Diagnose and Phenotype Asthma - 26/08/12
Doi : 10.1016/j.ccm.2012.05.003
Parameswaran Nair, MD, PhD, FRCP, FRCPC a, ⁎ 
, Angira Dasgupta, MD, MRCP (UK) a, Christopher E. Brightling, MB, PhD, FRCP b, Kian Fan Chung, MD, DSc, FRCP c
, Angira Dasgupta, MD, MRCP (UK) a, Christopher E. Brightling, MB, PhD, FRCP b, Kian Fan Chung, MD, DSc, FRCP c a Department of Medicine, St Joseph’s Healthcare, McMaster University, 50 Charlton Avenue East, Hamilton, Ontario L8N4A6, Canada
b Infection and Inflammation Institute, Glenfield Hospital, University of Leicester, Groby Road, Leicester, LE39QP, UK
c National Heart & Lung Institute, Imperial College & NIHR Biomedical Research Unit, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK
Corresponding author. Firestone Institute for Respiratory Health, St Joseph’s Healthcare, 50 Charlton Avenue East, Hamilton, Ontario L8N4A6, Canada.Résumé |
Asthma has been described as a chronic disease of the airways characterized by variable airflow obstruction, airway hyperresponsiveness, and airway inflammation. This review discusses the diagnosis and phenotyping of asthma, with a special emphasis on phenotyping based on the nature of cellular inflammation and radiological imaging and how this could be used to direct the treatment of asthma and, in the future, to apply specifically directed therapies to specific phenotypes.
Le texte complet de cet article est disponible en PDF.Keywords : Asthma, Phenotyping, Inflammation
Plan
| Dr Nair is supported by a Canada Research Chair in Airway Inflammometry. |
© 2012
Elsevier Inc. Tous droits réservés.
Vol 33 - N° 3
P. 445-457 - septembre 2012 Retour au numéro
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