Therapeutic Potential of Mesenchymal Stem Cells for Oral and Systemic Diseases - 25/07/12
Résumé |
Mesenchymal stem cells (MSCs) are adult stem cells whose self-renewal, multipotency, and immunosuppressive functions have been investigated for therapeutic applications. MSCs have used for various systemic organ regenerative therapies, allowing rescue of tissue function in damaged or failing organs. This article reviews the regenerative and immunomodulatory functions of MSCs and their applications in dental, orofacial, and systemic tissue regeneration and treatment of inflammatory disorders. It also addresses challenges to MSC-mediated therapeutics arising from tissue and MSC aging and host immune response against allogenic MSC transplantation, and discusses alternative sources of MSCs aimed at overcoming these limitations.
Le texte complet de cet article est disponible en PDF.Keywords : Mesenchymal stem cells, Tissue engineering, Immunosuppression, Epithelial–mesenchymal transition, Pulp capping, Pulp revitalization
Plan
Financial Disclosure: The current study was supported by grants DE18295 and DE18959 from NIDCR/NIH and by the Jack Weichman Endowed fund. |
Vol 56 - N° 3
P. 651-675 - juillet 2012 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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