Regenerative Endodontics : Barriers and Strategies for Clinical Translation - 25/07/12

Doi : 10.1016/j.cden.2012.05.005

Jeremy J. Mao, DDS, PhD ^a,^⁎ , Sahng G. Kim, DDS, MS ^a,^b, Jian Zhou, DDS, PhD ^a, Ling Ye, DDS, PhD ^c, Shoko Cho, MD, PhD ^a, Takahiro Suzuki, DDS, PhD ^a, Susan Y. Fu, MD, PhD ^a, Rujing Yang, MD ^a, Xuedong Zhou, DDS, PhD ^c
^a Center for Craniofacial Regeneration, Columbia University, 630 West 168 Street, PH7E, New York, NY 10032, USA
^b Division of Endodontics, College of Dental Medicine, Columbia University, 630 West 168 Street, PH7Stem #128, New York, NY 10032, USA
^c Department of Endodontics, West China School of Stomatology, Sichuan University, 14#, 3rd section of Ren Min Nan Lu, Chengdu, Sichuan, 610041, China

Corresponding author. Center for Craniofacial Regeneration, Columbia University, 630 West 168 Street, PH7E, New York, NY 10032.

Résumé

Regenerative endodontics has encountered substantial challenges toward clinical translation. The adoption by the American Dental Association of evoked pulp bleeding in immature permanent teeth is an important step for regenerative endodontics. However, there is no regenerative therapy for most endodontic diseases. Simple recapitulation of cell therapy and tissue engineering strategies that are under development for other organ systems has not led to clinical translation in regeneration endodontics. Recent work using novel biomaterial scaffolds and growth factors that orchestrate the homing of host endogenous cells represents a departure from traditional cell transplantation approaches and may accelerate clinical translation.

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Keywords : Regenerative, Endodontics, Pulp, Dentin, Regeneration, Stem cells, Tissue engineering

Plan

Introduction

Clinical studies of pulp revascularization

Regenerative endodontics: is it just a scientific exercise or can it become clinical treatments?

Challenge Number 1: What Cells Should Be Used for Pulp/Dentin Regeneration?

Challenge Number 2: What Scaffolding Material Should Be Used in Pulp/Dentin Regeneration?

Summary

	The work for composition of this article is supported by NIH grants R01DE018248, R01EB009663, and RC2DE020767 (to J.J.M.) as well as NSFC grants 81070801 (to L.Y.) and 30973324 (to X.D.Z.).
	Conflict of interest: Columbia University is the owner of patents for several regenerative endodontic agents and methods on behalf of Dr Jeremy Mao’s laboratory.