Prevalence of Hyponatremia at Diagnosis and Factors Associated with the Longitudinal Variation in Serum Sodium Levels in Infants with Cystic Fibrosis - 24/07/12
, Graziela C.M. Schettino, MD 1, 2, Paulo A.M. Camargos, MD, PhD 3, 4, Francisco J. Penna, MD, PhD 1, 2
Reprint requests: Elizabet V. Guimarães, PhD, Professor, Departamento de Pediatria, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.Abstract |
Objective |
To determine the prevalence of hyponatremia at diagnosis in patients with cystic fibrosis and identify the factors associated with changes in serum sodium concentration over time.
Study design |
This longitudinal study investigated whether variations in serum sodium concentration were associated with age, diet, infection status, and climate/temperature. Multivariate analysis was performed using the random-effects model for longitudinal data.
Results |
Hyponatremia at diagnosis was observed in 19 of the 20 patients (95%). Factors identified as associated with variations in serum sodium concentration were diet (P = .008) and climate/temperature (P = .005). Intake of solid foods appeared to greatly increase the serum sodium concentration (increase of 5 mEq/L after introduction of solid foods); however, a confounding factor between diet and age cannot be definitively ruled out. Climate/temperature contributed in an inverse way; a 1°C-increase in ambient temperature was associated with a 0.5-mEq/L decrease in serum sodium concentration.
Conclusion |
Infants with cystic fibrosis who feed on breast milk or formula and live in a high-temperature environment are at increased risk for hyponatremia, even when receiving a higher salt intake in accordance with recommendations.
Le texte complet de cet article est disponible en PDF.Mots-clés : CF, Pa, PI, Sa, WAZ
Plan
| Supported by the Brazilian research agencies CNPq-Conselho Nacional de Desenvolvimento Científico e Tecnológico-(grant 303827/2009-2, to P.C.) and Fundação de Amparo à Pesquisa do Estado de Minas Gerais (grant PPM-00230-10, to P.C.). These research agencies had no influence on study design; the collection, analysis, and interpretation of data; the writing of the report; or the decision to submit the manuscript for publication. The authors declare no conflicts of interest. |
Vol 161 - N° 2
P. 285-289 - août 2012 Retour au numéro
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