Correlates of Resistin in Children with Chronic Kidney Disease: The Chronic Kidney Disease in Children Cohort - 24/07/12
Reprint requests: Mark Mitsnefes, Division of Nephrology and Hypertension, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, ML 7022, Cincinnati, OH 45229.Abstract |
Objective |
To test the hypothesis that resistin is associated with insulin resistance and inflammation in pediatric patients with chronic kidney disease (CKD).
Study design |
This study is a cross-sectional analysis of 319 children in the Chronic Kidney Disease in Children cohort, a large cohort of children with stage II-IV CKD. Univariate and multivariate regression modeling was used to evaluate the association of serum resistin level with glomerular filtration rate (GFR), demographic data, and cardiovascular risk factors, including inflammatory cytokines, insulin resistance, and serum lipids.
Results |
In univariate analyses, serum resistin level was negatively correlated with GFR (P < .01). Increased serum resistin was associated with elevated inflammatory cytokines, including interleukin (IL)-6 (P < .01), IL-10 (P < .01), and tumor necrosis factor-⍺ (P < .01). Resistin level was not associated with insulin resistance, although it was positively correlated with serum triglycerides (P < .01) and negatively correlated with high-density lipoprotein cholesterol (P < .01). In multivariate analysis, GFR (β = −0.01; P < .001), IL-6 (β = 0.18; P < .001), IL-10 (β = 0.09; P = .01), and pubertal status (β = 0.18; P < .01) were significantly associated with serum resistin level.
Conclusion |
These results indicate that serum resistin level increases with GFR decline and is involved in the inflammatory milieu present in CKD.
Le texte complet de cet article est disponible en PDF.Mots-clés : BMI, CKiD, CKD, CVD, GFR, HOMA-IR, IL, TNF
Plan
| Supported by National Institute of Diabetes and Digestive and Kidney Diseases Research grant DK076957 (to M.M.). The Chronic Kidney Disease in Children study is funded by the National Institute of Diabetes and Digestive and Kidney Diseases, with additional funding from the National Institute of Neurological Disorders and Stroke, National Institute of Child Health and Human Development, and National Heart, Lung, and Blood Institute (grants U01-DK-66143, U01-DK-66174, U01-DK-82194, and U01-DK-66116). The authors declare no conflicts of interest. |
Vol 161 - N° 2
P. 276-280 - août 2012 Retour au numéro
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