Factors involved in the level of functioning of patients with schizophrenia according to latent variable modeling - 15/07/12
, O. Blanc a , L. Samalin a , M. Bosia b, R. Cavallaro bon behalf of the EGOFORS initiative
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Abstract |
Purpose |
This study aimed at using latent variable modelling to explore the significantly contributing variables to functioning in schizophrenia patients.
Methods |
The study cohort comprised 296 schizophrenia patients evaluated once for demographic characteristics, functioning (FROGS, SWN-K, QLS) and symptomatology (Positive and Negative Syndrome Scale [PANSS]). First exploratory multivariate analyses were conducted and then a model with functioning as a latent variable was proposed and tested with the data.
Results |
Symptomatology as negative, cognitive and excitation factor are significant predictors of functioning assessed through FROGS (P<0.0001), SWN-K and QLS (P<0.001). The model was constructed with functioning defined as a latent variable, indicators are subscores on FROGS, SWN-K, QLS and exogenous variable included symptomatology, Duration of Untreated Psychosis (DUP) and educational level.
Conclusion |
Using the five clinical dimensions of the PANSS, (Positive, Negative, Cognitive, Anxiety/Depression and Excitation) the negative and cognitive dimensions are highly correlated via the latent variable to the three dimensions of functioning evaluated by the FROGS: “daily life”, “social functioning” and “treatment” and the QLS subscores (interpersonnal, common object, instrumental role). Educationnal level is positively linked to functioning but not DUP. The model emphasizes the need for treatment strategies that have an effect on cognitive-factors, to improve functioning in schizophrenia.
Le texte complet de cet article est disponible en PDF.Keywords : Functioning, Cognitive and negative symptoms, Modeling, Schizophrenia
Plan
Vol 27 - N° 6
P. 396-400 - août 2012 Retour au numéro
Article précédent
- How are we assessing functioning in schizophrenia? A need for a consensus approach
- J. Peuskens, P. Gorwood, on behalf of the EGOFORS initiative
- Remitted but still impaired? Symptomatic versus functional remission in patients with schizophrenia
- A. Karow, S. Moritz, M. Lambert, D. Schöttle, D. Naber, on behalf of the EGOFORS initiative
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