Cerebral blood flow modulation by transcutaneous cranial electrical stimulation with Limoge’s current - 11/07/12
, M. Sesay b , L. Stinus c , R. Thiebaut d , M. Auriacombe e, f , V. Dousset a 
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Summary |
Objectives |
Transcutaneous cranial electrical stimulation (TCES) delivers a high-frequency (166kHz) pulsed biphasic balanced current with a pulse repetition frequency of 100Hz with 40% duty cycle through a negative electrode and two positive electrodes over the skull. TCES has a proven ability to potentiate anesthesia and analgesia, although the physiological mechanisms of this effect remain unclear. We hypothesized that the mechanism is a modulation of CBF in the central endogenous opioid system. This study aimed at determining the effects of TCES on CBF to elucidate its physiological mechanism.
Methods |
Thirty-six healthy volunteers were randomly assigned to active or placebo TCES, and all assessments were double blind. TCES was performed using the Anesthelec™ device. In the stimulated group, an active cable was used, and in the control group (sham), the cable was inactive. CBF was measured by XeCT™ before and after two hours of TCES.
Results |
Globally, CBF was unchanged by TCES. However, locally, TCES induced a significant CBF decrease in the brainstem and thalamus, which are structures involved in pain and anxiety (TCES and control CBF decrease were 18.5 and 11.9mL/100g brain tissue/min, respectively).
Conclusion |
TCES can modulate local CBF but it has no effect on overall CBF. [Clinical Trials. gov number: NCT00273663].
Le texte complet de cet article est disponible en PDF.Keywords : Cerebral blood flow, Transcutaneous electrical stimulation, Brain stimulation, Xenon CT, Brain mapping analyzer
Abbreviations : TCES, CBF, rCBF, XeCT, PET, fMRI, AMY, HIP, INS, BST, STR, THA, CIN, FRO, RCT, OM, SEM, ICC
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Vol 39 - N° 3
P. 167-175 - juillet 2012 Retour au numéro
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