Variation in the BDNF Val66Met polymorphism and response to cognitive-behavior therapy in obsessive-compulsive disorder - 19/06/12
, P. Alonso c, d, e, M. Gratacòs f, g, N. Jaurrieta c, S. Jiménez-Murcia c, e, C. Segalàs c, E. Real h, X. Estivill f, g, i, j, J.M. Menchón c, d, e
Corresponding author. King’s College London, Institute of Psychiatry, PO69 De Crespigny Park Road, SE5 8AF, London, United Kingdom. Tel.: +44 2078 480 543; fax: +44 2078 480 379.Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Background |
Recent research suggests that the brain-derived neurotrophic factor (BDNF) may play a role in extinction learning. The goal of this study was to test whether variation in the BDNF Val66Met polymorphism is related to treatment response to exposure-based cognitive-behavior therapy (CBT), a form of extinction learning, in obsessive-compulsive disorder (OCD).
Methods |
One hundred and six OCD patients from a specialized clinic, who underwent a standardized CBT treatment after partial or non-response to a 12-week pharmacological trial, were genotyped for the BDNF Val66Met and the relationship between genotype and treatment response was analyzed.
Results |
Among 98 CBT completers, 36% of those carrying the BDNF Met allele were rated as CBT responders compared to 60% of nonMet allele carriers (P=0.027). When analyzing the different obsessive-compulsive symptom dimensions, in patients with contamination/cleaning symptoms, the Met allele was associated with a significantly worse CBT response (P<0.0001) and a lower obsessions severity decrease from pre- to posttreatment (P=0.046).
Conclusion |
Genetic variation in BDNF may be associated with treatment response in exposure-based CBT in OCD, especially in those patients exhibiting contamination/cleaning symptoms.
Le texte complet de cet article est disponible en PDF.Keywords : Obsessive-compulsive disorder, Extinction, Cognitive-behavior therapy, Genetics, BDNF, Val66Met
Plan
Vol 27 - N° 5
P. 386-390 - juillet 2012 Retour au numéro
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