O-49 - Effects of levetiracetam on the development and expression of tolerance to morphine-induced antinociception in mice - 13/06/12
Résumé |
Aims |
In the present study, the effects of Levetiracetam on the development and expression of tolerance to the morphine-induced antinociception was evaluated using tail-flick test.
Methods |
To assess the Levetiracetam effects on tolerance development, the animals received Levetiracetam (60, 300 or 900mg/kg; i.p.), 30min prior to morphine (50mg/kg; s.c.) administration during tolerance induction period once daily for 3 days. Also, to evaluate the effects of Levetiracetam on tolerance expression, different doses of Levetiracetam was administered 30min before challenge dose of morphine (5mg/kg; s.c.) following morphine-induced tolerance. In each experiment the antinociceptive response to the challenge dose of morphine was evaluated after 30-min interval by tail-flick test. Furthermore, the analgesic effect of various doses of Levetiracetam alone was evaluated as well.
Results |
The results showed that Levetiracetam at the doses of 300 and 900mg/kg could inhibit the development of tolerance. Also, Levetiracetam at the dose of 900mg/kg attenuated the expression of morphine-induced tolerance. Levetiracetam injection was associated significantly with higher latency period when compared to the control group. Moreover, Levetiracetam (900mg/kg) significantly enhanced antinociceptive effect of morphine in a dose-dependent manner.
Conclusions |
These data indicated that, while Levetiracetam can attenuate both development and expression of morphine-induced tolerance, it can enhance morphine-induced antinociception. These effects may have important clinical implications.
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