P-798 - Functional connectivity of motor control in attention deficit hyperactivity disorder (ADHD) and pediatric bipolar disorder (PBD) with and without ADHD - 13/06/12
Résumé |
Introduction |
ADHD and PBD are two developmental syndromes with high comorbidity rates and common symptoms of inattention, impulsivity and hyperactivity.
Objectives |
Mechanistic comprehension of neural circuitry function will enhance our understanding of the dimensional functions of affect and cognition, and guide rational pharmacological treatment for ADHD and PBD.
Aims |
The aim of this research is to further examine the neural bases of impulsivity in distributed brain networks engaged during execution or inhibition of a pre-potent motor response in adolescents with PBD and ADHD relative to healthy controls (HC).
Methods |
31 adolescents with PBD, 24 PBD/ADHD, 22 ADHD and 33 HC (mean age 13.78±2.4), underwent fMRI stop signal task, examining the ability to inhibit a prepotent motor response.
Results |
Relative to HC, ADHD showed greater connectivity in bilateral cerebellum and decreased connectivity in left precuneus and subgenual ACC (Figure 1, Panel A). The PBD/ADHD group’s functional connectivity was reduced in limbic regions relative to the other three groups, while it was increased in right insula relative to ADHD (Figure 1, Panel B).
Conclusions |
Findings suggest that within an attentional control network relative to HC, both PBD and ADHD groups exhibit greater functional connectivity in right VLPFC. The PBD/ADHD group showed more severe PBD-like pattern of over-engagement in emotional regions, and a less severe ADHD-like pattern in posterior attentional regions.
Figure 1: During Behavior Inhibition.
Figure 1: During Behavior Inhibition.Le texte complet de cet article est disponible en PDF.
Vol 27 - N° S1
P. 1 - 2012 Retour au numéro
Article précédent
- P-797 - Residual cognitive impairment in patients affected by bipolar disorder during euthymia: an assessment with functional magnetic resonance imaging (fMRI)
- M. Palazzo, M. Cristoffanini, C. Dobrea, C. Cinnante, S. Avignone, C. Sina, L. Cremaschi, A. Sillani, B. Dell’Osso, F.M. Triulzi, A.C. Altamura
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- J. Radua, W. El-Hage, G.C. Monté, B. Gohier, M. Tropeano, M.L. Phillips, S. Surguladze
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