The efficacy of the treatment of personality disorder was repeatedly been reported as less successful than the therapy of patients without personality disorder. Our study is designed to compare the short-term effectiveness of therapy in patient suffering with social phobia with and without personality disorder.

The aim of the study was to asses the efficacy of the 6 week therapeutic program designed for social phobia (SSRIs and CBT) in patients suffering with social phobia and comorbid personality disorder (27 patients) and social phobia without comorbid personality disorder (26 patients). Patients were assessed in week 0, 2, 4, and 6 on the CGI, LSAS, BAI and BDI.

Patients of both two groups improved in assessment instruments. The treatment efficacy in the patients with social phobia without personality disorder had been showed significantly better compared with the group with social phobia comorbid with personality disorder in CGI and LSAS. Also the scores in subjective depression inventory BDI showed significantly higher degrease during the treatment in the group without personality disorder. But the treatment effect between groups did not differ in subjective general anxiety scales BAI.

The low frequency rTMS administered over the right dorso-lateral prefrontal cortex after 10sessions did not differ from sham rTMS that was add on serotonin reuptake inhibitors in patients suffering from panic disorder. Further studies are indicated to assess the efficacy of rTMS in panic disorder and to clarify the optimal stimulation characteristics.

By IGA MZ CR NT 11047-4/2010.