African ancestry and lung function in Puerto Rican children - 31/05/12

Doi : 10.1016/j.jaci.2012.03.035

John M. Brehm, MD, MPH ^a, Edna Acosta-Pérez, PhD ^b, Lambertus Klei, PhD ^c, Kathryn Roeder, PhD ^d, Michael M. Barmada, PhD ^e, Nadia Boutaoui, PhD ^a, Erick Forno, MD, MPH ^f, Michelle M. Cloutier, MD ^g, Soma Datta, MS ^h, Roxanne Kelly, MBA ^h, Kathryn Paul, BS ^h, Jody Sylvia, MS ^h, Deanna Calvert, BS ⁱ, Sherell Thornton-Thompson, CCRP ⁱ, Dorothy Wakefield, MS ^g, Augusto A. Litonjua, MD, MPH ^h, María Alvarez, MD ^b, Angel Colón-Semidey, MD ^b, Glorisa Canino, PhD ^b, Juan C. Celedón, MD, DrPH ^a,^⁎
^a Division of Pediatric Pulmonary Medicine, Allergy and Immunology, Department of Pediatrics, Children’s Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pa
^b Behavioral Sciences Research Institute, University of Puerto Rico, San Juan, Puerto Rico
^c Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pa
^d Department of Statistics, Carnegie Mellon University, Pittsburgh, Pa
^e Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa
^f Division of Pediatric Pulmonology, Department of Pediatrics, University of Miami, Miami, Fla
^g Department of Pediatrics, University of Connecticut Health Center, Farmington, Conn
^h Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, Boston, Mass
ⁱ Connecticut Children’s Medical Center, Hartford, Conn

Corresponding author: Juan C. Celedón, MD, DrPH, Division of Pediatric Pulmonary Medicine, Allergy and Immunology, Department of Pediatrics, Children’s Hospital of Pittsburgh of UPMC, 4401 Penn Ave, Pittsburgh, PA 15224.

Abstract

Background

Puerto Rican and African American subjects share a significant proportion of African ancestry. Recent findings suggest that African ancestry influences lung function in African American adults.

Objective

We sought to examine whether a greater proportion of African ancestry is associated with lower FEV₁ and forced vital capacity (FVC) in Puerto Rican children independently of socioeconomic status, health care access, or key environmental/lifestyle factors.

Methods

We performed a cross-sectional case-control study of 943 Puerto Rican children aged 6 to 14 years with (n = 520) and without (n = 423) asthma (defined as physician-diagnosed asthma and wheeze in the prior year) living in Hartford, Connecticut (n = 383), and San Juan, Puerto Rico (n = 560). We estimated the percentage of African racial ancestry in study participants using genome-wide genotypic data. We tested whether African ancestry is associated with FEV₁ and FVC using linear regression. Multivariate models were adjusted for indicators of socioeconomic status and health care and selected environmental/lifestyle exposures.

Results

After adjustment for household income and other covariates, each 20% increment in African ancestry was significantly associated with lower prebronchodilator FEV₁ (−105 mL; 95% CI, −159 to −51 mL; P < .001) and FVC (−133 mL; 95% CI, −197 to −69 mL; P < .001) and postbronchodilator FEV₁ (−152 mL; 95% CI, −210 to −94 mL; P < .001) and FVC (−145 mL; 95% CI, −211 to −79 mL; P < .001) in children with asthma. Similar but weaker associations were found for prebronchodilator and postbronchodilator FEV₁ (change for each 20% increment in African ancestry, −78 mL; 95% CI, −131 to −25 mL; P = .004) and for postbronchodilator FVC among children without asthma.

Conclusions

Genetic factors, environmental/lifestyle factors, or both correlated with African ancestry might influence childhood lung function in Puerto Rican subjects.

Le texte complet de cet article est disponible en PDF.

Key words : Ancestry, FEV₁, forced vital capacity, Puerto Ricans, childhood

Abbreviations used : BMI, ETS, FVC, ICS, LAMP, PSU, SES, SNP

Plan

Subjects’ characteristics and estimation of racial ancestry

Bivariate analysis

Multivariate analysis

Discussion

Supported by National Institutes of Health (NIH) grant R01HL079966. J.M.B. receives support from NIH grant K12HD052892. Supported in part by Children's Hospital of Pittsburgh of the UPMC Health System.

Disclosure of potential conflict of interest: A. A. Litonjua has received research support from the National Institutes of Health and has received author royalties from UpToDate, Inc. J. C. Celedón is on the advisory board for Genentech, has received research support from the National Institutes of Health, and has received author royalties from UpToDate. The rest of the authors declare that they have no relevant conflicts of interest.

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Vol 129 - N° 6

P. 1484 - juin 2012 Retour au numéro

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African ancestry and lung function in Puerto Rican children - 31/05/12

Abstract

Background

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