Effect of secondhand smoke on asthma control among black and Latino children - 31/05/12
, Haig Tcheurekdjian, MD c, d, Lindsey A. Roth, MA a, Elizabeth A. Nguyen, BS a, Saunak Sen, PhD e, Joshua M. Galanter, MD a, Adam Davis, MA, MPH f, Harold J. Farber, MD, MSPH g, Frank D. Gilliland, MD, PhD h, Rajesh Kumar, MD, MS i, Pedro C. Avila, MD j, Emerita Brigino-Buenaventura, MD k, Rocio Chapela, MD l, Jean G. Ford, MD m, Michael A. LeNoir, MD n, Fred Lurmann, MS o, Kelley Meade, MD f, Denise Serebrisky, MD p, Shannon Thyne, MD q, William Rodriguez-Cintron, MD r, Jose R. Rodriguez-Santana, MD s, L. Keoki Williams, MD, MPH t, u, Luisa N. Borrell, DDS, PhD v, Esteban G. Burchard, MD, MPH a
Corresponding author: Sam S. Oh, PhD, MPH, Departments of Bioengineering & Therapeutic Sciences and Medicine, UCSF/Mission Bay/Lung Biology Center, Rock Hall, Rm 582, 1550 4th Street, San Francisco, CA 94158-2911.Abstract |
Background |
Among patients with asthma, the clinical effect and relative contribution of maternal smoking during pregnancy (in utero smoking) and current secondhand smoke (SHS) exposure on asthma control is poorly documented, and there is a paucity of research involving minority populations.
Objectives |
We sought to examine the association between poor asthma control and in utero smoking and current SHS exposure among Latino and black children with asthma.
Methods |
We performed a case-only analysis of 2 multicenter case-control studies conducted from 2008-2010 with similar protocols. We recruited 2481 Latino and black subjects with asthma (ages 8-17 years) from the mainland United States and Puerto Rico. Ordinal logistic regression was used to estimate the effect of in utero smoking and current SHS exposures on National Heart, Lung, and Blood Institute–defined asthma control.
Results |
Poor asthma control among children 8 to 17 years of age was independently associated with in utero smoking (odds ratio [OR], 1.5; 95% CI, 1.1-2.0). In utero smoking through the mother was also associated with secondary asthma outcomes, including early-onset asthma (OR, 1.7; 95% CI, 1.1-2.4), daytime symptoms (OR, 1.6; 95% CI, 1.1-2.1), and asthma-related limitation of activities (OR, 1.6; 95% CI, 1.2-2.2).
Conclusions |
Maternal smoking while in utero is associated with poor asthma control in black and Latino subjects assessed at 8-17 years of age.
Le texte complet de cet article est disponible en PDF.Key words : Secondhand smoke, prenatal exposure delayed effects, asthma, health status disparities
Abbreviations used : FVC, GALA II, NHLBI, OR, SAGE II, SHS
Plan
| Supported in part by the National Institutes of Health (ES015794, AI077439, HL088133, HL078885, CA113710, AI079139, AI061774, HL079055, DK064695, and M01-RR00188), the Flight Attendant Medical Research Institute (FAMRI), the RWJF Amos Medical Faculty Development Award (to E.G.B.), the Sandler Foundation, the American Asthma Foundation (to E.G.B. and L.K.W.), an Ernest S. Bazley Grant (to P.C.A.), and the Fund for Henry Ford Hospital (to L.K.W.). S.S.O. and E.G.B. had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. |
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| Disclosure of potential conflict of interest: S. Sen and J. M. Galanter have received research support from the National Institutes of Health. A. Davis has received research support from the Sandler Foundation. H. J. Farber is a scientific journal editor for Mary Anne Liebert, Inc, and has received research support from the National Institutes of Health. R. Kumar has received research support from the National Institutes of Health/National Heart, Lung, and Blood Institute. P. C. Avila receives research support from the National Institutes of Health and is on the data and safety monitoring boards for Astellas and Biota. J. G. Ford has consultant arrangements with GlaxoSmithKline. K. Meade receives research support from AsthmaNet–National Institutes of Health. L. K. Williams receives research support from the National Institute of Allergy and Infectious Diseases and the National Heart, Lung, and Blood Institute. The rest of the authors declare that they have no relevant conflicts of interest. |
Vol 129 - N° 6
P. 1478 - juin 2012 Retour au numéro
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