Temporal alterations in vascular angiotensin receptors and vasomotor responses in offspring of protein-restricted rat dams - 24/05/12
Reprints: Chandra Yallampalli, DVM, PhD, Distinguished Professor, Obstetrics and Gynecology, The University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-1062Résumé |
Objective |
Examine temporal alterations in vascular angiotensin II receptors (AT1R and AT2R) and determine vascular response to angiotensin II in growth-restricted offspring.
Study Design |
Offspring of pregnant rats fed low-protein (6%) and control (20%) diet were compared.
Results |
Prenatal protein restriction reprogrammed AT1aR messenger RNA expression in male rats' mesenteric arteries to cause 1.7- and 2.3-fold increases at 3 and 6 months of age associated with arterial pressure increases of 10 and 33 mm Hg, respectively; however, in female rats, increased AT1aR expression (2-fold) and arterial pressure (15 mm Hg) occurred only at 6 months. Prenatal protein restriction did not affect AT2R expression. Losartan abolished hypertension, suggesting that AT1aR plays a primary role in arterial pressure elevation. Vasoconstriction to angiotensin II was exaggerated in all protein-restricted offspring, with greater potency and efficacy in male rats.
Conclusion |
Prenatal protein restriction increased vascular AT1R expression and vasoconstriction to angiotensin II, possibly contributing to programmed hypertension.
Le texte complet de cet article est disponible en PDF.Key words : angiotensin, fetal programming, hypertension, intrauterine growth restriction, rats, vascular
Plan
| The findings reported in this article result from the National Institutes of Health (NIH) grant numbers HL102866 and HL 58144. |
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| The authors report no conflict of interest. |
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| Cite this article as: Sathishkumar K, Balakrishnan M, Chinnathambi V, et al. Temporal alterations in vascular angiotensin receptors and vasomotor responses in offspring of protein-restricted rat dams. Am J Obstet Gynecol 2012;206:507.e1-10. |
Vol 206 - N° 6
P. 507.e1-507.e10 - juin 2012 Retour au numéro
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