Clustering of maternal–fetal clinical conditions and outcomes and placental lesions - 24/05/12
Résumé |
Objective |
To identify by an inductive statistical analysis mutually similar and clinically relevant clinicoplacental clusters.
Study Design |
Twenty-nine maternofetal and 49 placental variables have been retrospectively analyzed in a 3382 case clinicoplacental database using a hierarchical agglomerative Ward dendrogram and multidimensional scaling.
Results |
The exploratory cluster analysis identified 9 clinicoplacental (macerated stillbirth, fetal growth restriction, placenta creta, acute fetal distress, uterine hypoxia, severe ascending infection, placental abruption, and mixed etiology [2 clusters]), 5 purely placental (regressive placental changes, excessive extravillous trophoblasts, placental hydrops, fetal thrombotic vasculopathy, stem obliterative endarteritis), and 1 purely clinical (fetal congenital malformations) statistically significant clusters/subclusters. The clusters of such variables like clinical umbilical cord compromise, preuterine and postuterine hypoxia, gross umbilical cord or gross chorionic disk abnormalities did not reveal statistically significant stability.
Conclusion |
Although clinical usefulness of several well-established placental lesions has been confirmed, claims about high predictability of others have not.
Le texte complet de cet article est disponible en PDF.Key words : in-utero hypoxia, placenta, preeclampsia, uteroplacental insufficiency, uteroplacental malperfusion
Plan
| The authors report no conflict of interest. |
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| Reprints not available from the authors. |
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| Cite this article as: Stanek J, Biesiada J. Clustering of maternal–fetal clinical conditions and outcomes and placental lesions. Am J Obstet Gynecol 2012;206:493.e1-8. |
Vol 206 - N° 6
P. 493.e1-493.e8 - juin 2012 Retour au numéro
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