β-Cell Dysfunction in Adolescents and Adults with Newly Diagnosed Type 2 Diabetes Mellitus - 23/05/12
, Patricia M. Herbers, MS 2, Tammy Weis, RN 1, Debra Standiford, RN, MSN, CNP 1, Jessica G. Woo, PhD 2, David A. D’Alessio, MD 3
Reprint requests: Deborah A. Elder, MD, Cincinnati Children’s Hospital Medical Center MLC 7012, 3333 Burnet Ave, Cincinnati, OH 45229.Abstract |
Objective |
To compare β-cell function in adolescents and adults with newly diagnosed type 2 diabetes (T2DM).
Study design |
Thirty-nine adolescents with T2DM, 38 age- and weight-matched control subjects, and 19 adults with T2DM were studied. The adolescent subjects with diabetes were divided on the basis of whether they needed insulin to control their initial hyperglycemia. The primary outcome variable was the disposition index, computed from the acute insulin response to glucose corrected for insulin sensitivity (1/Homeostatic model assessment of insulin resistance).
Results |
The disposition index was significantly reduced in all 3 diabetic groups (control n=3360, adolescents with T2DM without insulin n=630, adolescents with T2DM with insulin n=120, adults with T2DM n=200; P<.001), and the adolescents with more severe hyperglycemia at diagnosis had lower disposition index than those with a more modest presentation (P<.05).
Conclusion |
At the time of diagnosis, adolescents with T2DM have significant β-cell dysfunction, comparable with adults newly diagnosed with T2DM. Thus, severe β-cell impairment can develop within the first two decades of life and is likely to play a central role in the pathogenesis of T2DM in adolescents.
Le texte complet de cet article est disponible en PDF.Mots-clés : AIRARG, AIRg, HbA1c, HOMA-IR, PI/I, T2DM
Plan
| Funded by National Center for Research Resources (National Institutes of Health 5K23DK070775-03 to D.E. and R01DK57900 to D.D.), M01 RR 08084, and US Public Health Service (grant #UL1 RR026314). The authors declare no conflicts of interest. |
Vol 160 - N° 6
P. 904-910 - juin 2012 Retour au numéro
Article précédent
- Growth in Children and Adolescents with Type 1 Diabetes
- Walter Bonfig, Thomas Kapellen, Axel Dost, Maria Fritsch, Tilman Rohrer, Johannes Wolf, Reinhard W. Holl, Diabetes Patienten Verlaufsdokumentationssystem Initiative of the German Working Group for Pediatric Diabetology and the German Bundesministerium für Bildung und Forschung Competence Net for Diabetes Mellitus ∗
- Health-Related Quality of Life in Adolescents with or at Risk for Type 2 Diabetes Mellitus
- Erinn T. Rhodes, Michael I. Goran, Tracy A. Lieu, Robert H. Lustig, Lisa A. Prosser, Thomas J. Songer, Marc J. Weigensberg, Ruth S. Weinstock, Tessa Gonzalez, Kaitlin Rawluk, Roula M. Zoghbi, David S. Ludwig, Lori M. Laffel
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?