A critical reappraisal of the current data on drug-induced linear immunoglobulin A bullous dermatosis: A real and separate nosological entity? - 13/05/12
, Julio Cesar Salas-Alanis, MD c, Eugenio Guidetti, DMD d, M. Peter Marinkovich, MD a, e
Reprint requests: Giulio Fortuna, Stanford University School of Medicine, Center for Clinical Sciences Research, Program in Epithelial Biology, Marinkovich Lab, 269 Campus Dr, Stanford, CA 94305.Abstract |
Background |
Linear IgA disease (LAD) has been associated with a variety of drugs over the past 30 years.
Objective |
To review current literature on all available cases of drug-induced LAD, in order to ascertain whether a close relationship is justified, so that it constitutes a real and separate nosological entity.
Methods |
The PubMed database was searched for all articles written in English related to drug-induced LAD published between January 1980 and December 2010.
Results |
The literature review shows that at least 84 articles were published, describing a total of 103 patients. Of these articles, only 46, from 13 countries, were included in this analysis, with a total of 52 patients: 24 (46.2%) were believed to be induced by vancomycin and 28 (53.8%) by drugs other than vancomycin. Challenge-dechallenge-rechallenge testing protocol was performed on only 6 (11.5%) of 52 patients, of which only 5 showed a positive result, while the Naranjo algorithm was performed on only 2 of them (0.3%).
Limitations |
The evidence of this review analysis is based only on case reports. No study on large samples of drug-induced LAD is currently available.
Conclusions |
The literature analysis reveals no strong scientific evidence to support the notion that some drugs have induced LAD; therefore in many reviewed cases, we must question whether drug-induced LAD is really the underlying entity. Further and thorough investigations using one of the available algorithms for adverse drug reaction are warranted.
Le texte complet de cet article est disponible en PDF.Abbreviations used : ADR, CDR, CI, DIF, LABD, LAD, OR, VILAD
Plan
| Funding sources: Office of Research and Development, Palo Alto Veterans Affairs Medical Center, Palo Alto, CA, and the School of Doctorate, Department of Odontostomatological and Maxillofacial Sciences, Federico II University of Naples, Naples, Italy. |
|
| Conflicts of interest: None declared. |
Vol 66 - N° 6
P. 988-994 - juin 2012 Retour au numéro
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