Does brachydactyly have a protective effect on the erosive changes in rheumatoid arthritis? - 05/05/12
Corresponding author. Tel.: +822-2290-9244; fax: +822-2298-8231.Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 3 |
| Iconographies | 0 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Objective |
Brachydactyly (BD) is a general term for inappropriately short fingers and/or toes. The author previously reported that a short metacarpal bone had a protective effect on the metacarpophalangeal joint of the same finger in rheumatoid arthritis (RA). The objective was to investigate the prevalence of BD in patients with RA and its potential effect on the phenotype, especially erosive changes.
Methods |
A total of 1524 Korean patients with RA were recruited. The presence of BD on hand radiographs, rheumatoid factor (RF), anti-cyclic citrullinated peptide antibody (anti-CCP), HLA-DRB1 shared epitopes (SE), risk haplotypes of peptidyl deiminase type IV (PADI4) and erosive joint stage, and smoking status, were determined.
Results |
The prevalence of BD was 7.9% (n=120) in our RA cohort. The types of BD were type A3 (79.2%), type D (15.0%), Kirner deformity (14.2%), and type E (6.7%). RA patients with BD had reduced erosion on hand radiographs (OR=0.57, 95% CI: 0.34–0.95, p=0.029) adjusted for age, sex, disease duration, smoking, RF, anti-CCP, SE, and PADI4.
Conclusion |
BD is more common in RA patients than might be expected. BD may have a protective effect on erosive changes in RA independent of previously well-established risk factors such as seropositivity, SE, PADI4, and smoking.
Le texte complet de cet article est disponible en PDF.Keywords : Rheumatoid arthritis, Brachydactyly, HOXD gene
Plan
Vol 79 - N° 3
P. 271-273 - mai 2012 Retour au numéro
Article précédent
- Usefulness of routine hepatitis C and hepatitis B serology in the diagnosis of recent-onset arthritis. Systematic prospective screening in all patients seen by the rheumatologists of a defined area – Brief report
- Thiphaine Ansemant, Paul ornetti, Jean-François Garrot, Françoise Pascaud, Christian Tavernier, Jean-Francis Maillefert
- Subclinical renal involvement in essential cryoglobulinemic vasculitis and classic polyarteritis nodosa
- Tamer A. Gheita, Nermeen A. Khairy, Mohamed M. Nasrallah, Hani Hussein
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?