Cardiovascular and metabolic risk in outpatients with schizoaffective disorder treated with antipsychotics: Results from the CLAMORS study - 27/04/12
, C. Arango b, P. Aranda c, R. Carmena d, M. Garcia-Garcia e, J. Rejas fon behalf of the CLAMORS Study Collaborative Group1
Corresponding author. Tel.: +34 985 10 35 53; fax: +34 985 10 35 53.Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 8 |
| Iconographies | 2 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Aim |
To assess the coronary heart disease (CHD) risk and prevalence of the metabolic syndrome (MS) in patients with schizoaffective disorder (SD) receiving antipsychotics.
Methods |
Patients meeting DSM-IV criteria for SD and receiving antipsychotic treatment were recruited in a retrospective, cross-sectional, multicenter study (the CLAMORS study). MS was defined as at least three of the following components: waist circumference greater than 102cm (men)/greater than 88cm (women); serum triglycerides greater or equal to 150mg/dl; HDL cholesterol less than 40mg/dl (men)/less than 50mg/dl (women); blood pressure greater or equal to 130/85mmHg; fasting blood glucose greater or equal to 110mg/dl. The 10-year CHD risk was assessed by the Systematic coronary risk evaluation (SCORE) (cardiovascular mortality) and Framingham (any cardiovascular event) functions. Clinical severity was assessed using the PANSS and CGI-S scales.
Results |
A total of 268 valuable patients with SD (127 men, 48.1%), 41.9±12.3years (mean±S.D.), were analyzed. The 10-year overall cardiovascular mortality and CV-event risk were 0.8±1.6 (SCORE) and 6.5±6.8 (Framingham), respectively. A high/very high risk of any CV event (Framingham≥10%) was associated with severity [CGI-S=3–4; OR: 4.32 (1.15–16.26), P=0.03)]. MS was present in 26.5% (95%CI: 21.2–31.8) of subjects, without gender differences, but significantly associated with patient’s impression of severity: CGI=3–4; OR=1.90 (0.83–4.36), and CGI=5–7; OR=3.13 (1.06–9.24), P=0<0.001, and age [OR=1.91 (1.09–3.34), P<0.024)].
Conclusions |
CHD risk and MS prevalence were high among patients with SD, being MS prevalence associated with age and severity of disease.
Le texte complet de cet article est disponible en PDF.Keywords : Metabolic syndrome, Cardiovascular risk, Schizoaffective disorders, Outpatients, Antipsychotic treatment, Mental status
Plan
Vol 27 - N° 4
P. 267-274 - mai 2012 Retour au numéro
Article précédent
- Perceived negative attitude of others predicts transition to psychosis in patients at risk of psychosis
- R.K.R. Salokangas, P. Patterson, M. Heinimaa, T. Svirskis, T. From, L. Vaskelainen, J. Klosterkötter, S. Ruhrmann, H.G. von Reventlow, G. Juckel, D. Linszen, P. Dingemans, M. Birchwood, the EPOS Group
- The effects of guided discontinuation of antipsychotics on neurocognition in first onset psychosis
- G. Faber, H.G.O.M. Smid, A.R. Van Gool, D. Wiersma, R.J. Van Den Bosch
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?