Antiangiogenic and cytotoxic activity of boswellic acid on breast cancer MCF-7 cells - 14/03/12
Abstract |
Boswellic acid possesses anticancer activity, however, its underlying mechanism(s) remain unexplored. Here, we report boswellic acid as a potent anticancer agent that acts against multiple intracellular targets that affect angiogenesis (VEGF), inflammation (TNF-⍺, IL-12), apoptosis (caspase-3 & -9) and antioxidant (SOD & CAT) based anticarcinogenic mechanisms. It inhibits MCF-7 cell proliferation and potentiates the cell death induced by VEGF antibody. A dose-dependent decrease in the levels of VEGF and TNF-⍺ and significant increase in caspases-3 and -9 activities in MCF-7 cells were observed. To conclude, the results of the present study suggest that boswellic acts via multiple albeit specific molecular targets to elicit anticarcinogenic activity.
Le texte complet de cet article est disponible en PDF.Keywords : Boswellic acid MCF-7, Vascular endothelial growth factor, Apoptosis, Angiogenesis
Plan
Vol 2 - N° 1
P. 31-37 - janvier 2012 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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