Associations of vitamin D receptor gene polymorphisms FokI and BsmI with susceptibility to rheumatoid arthritis and Behçet’s disease in Tunisians - 03/03/12
, Imen Ben Dhifallah a, ⁎ , Kawther Ben Abdelghani b, Imed Ben Ghorbel c, Monia Khanfir c, Habib Houman c, Kamel Hamzaoui a, Leith Zakraoui b
Corresponding author. Tunis University of Medicine, 15, rue Djebel Lakdar, 1007 Tunis, Tunisia.Co-corresponding author.Bienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Objectives |
Reports of immunomodulating effects of vitamin D suggest a need for examining allele and genotype frequencies of the vitamin D nuclear receptor gene (VDR) in patients with autoimmune diseases. T-helper-1 (Th1) counts in peripheral blood are increased in both rheumatoid arthritis (RA) and Behçet’s disease (BD). We studied VDR polymorphisms in patients with these two diseases in Tunisia.
Methods |
In 108 patients with RA, 131 patients with BD, and 152 controls, we studied FokI and BsmI VDR polymorphisms, using the restriction fragment length polymorphism technique.
Results |
The FokI polymorphism alleles and genotype were significantly more common in the RA group than in the controls (P=0.001 and P=0.005, respectively). The FokI F allele and F/F genotype were significantly associated with BD (P=0.0003 and P=0.002, respectively). Furthermore, in the group with BD, the FokI polymorphism was significantly associated with the presence of vascular manifestations (P=0.006). In patients with RA, the FokI polymorphism was significantly associated with female gender (P=0.003). No significant associations were found between the Bsm1 polymorphism and RA or BD.
Conclusion |
The VDR F allele is associated with RA and BD in Tunisians.
Le texte complet de cet article est disponible en PDF.Keywords : Vitamin D receptor, Behçet’s disease, Rheumatoid arthritis, Gene polymorphism
Plan
Vol 79 - N° 2
P. 144-148 - mars 2012 Retour au numéro
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