Prevalence and Risk Factors for Feeding and Swallowing Difficulties in Spinal Muscular Atrophy Types II and III - 12/02/12
Reprint requests: Yuh-Jyh Jong, MD, Department of Pediatrics, Kaohsiung Medical University Hospital, 100, Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan.Abstract |
Objective |
To identify the prevalence and risk factors of feeding and swallowing problems in patients with type II and type III spinal muscular atrophy (SMA).
Study design |
Cross-sectional data from 108 genetically confirmed patients with SMA (age range, 3-45 years; 60 with type II and 48 with type III) were analyzed. The questionnaire survey included demographic data, current motor function and respiratory status, feeding and swallowing difficulties, and consequences. The risk factors were analyzed via logistic regression.
Results |
The 3 most common feeding and swallowing difficulties in patients with type II and III SMA were choking (30.6%), difficulty conveying food to the mouth (20.4%), and difficulty chewing (20.4%). Current motor function status was an independent risk factor for feeding and swallowing difficulties (sitters vs walkers: OR, 7.59; 95% CI, 1.22-47.46). All 4 nonsitters (ie, patients with type II SMA who had lost their sitting ability) had feeding and swallowing difficulties. Patients with feeding and swallowing difficulties had significantly higher rates of underweight and aspiration pneumonia than those without these problems.
Conclusion |
Patients with type II and III SMA have a high prevalence of risk factors for feeding and swallowing difficulties, suggesting that an individualized treatment plan should depend on current motor function status.
Le texte complet de cet article est disponible en PDF.Mots-clés : SMA, SMN1, SMN2, W/A
Plan
| Supported in part by the Kaohsiung Medical University-Spinal Muscular Atrophy Fund, Kaohsiung Medical University. Y-J.J. holds patents for hydroxyurea treatment for spinal muscular atrophy and the method for diagnosing spinal muscular atrophy; he also serves as editor-in-chief of Pediatrics and Neonatology. The other authors declare no conflicts of interest. |
Vol 160 - N° 3
P. 447 - mars 2012 Retour au numéro
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