Role of the purinergic system in patients with cervical intraepithelial neoplasia and uterine cancer - 07/02/12
, Victor Camera Pimentel, Luiz Augusto Negrini, Vera Maria Morsch, Maria Rosa Chitolina Schetinger
Corresponding author. Tel.: +55 32 20 86 65; fax: +55 32 20 89 78; +55 96 07 71 78.Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
| pages | 6 |
| Iconographies | 5 |
| Vidéos | 0 |
| Autres | 0 |
Abstract |
Introduction |
Cervical cancer remains the second leading cause of death among women. Intraepithelial neoplasias and uterine invasive cancer are frequently associated with disturbances in coagulation and changes in the concentrations of adenine nucleotides. This work intended to analyze changes in extracellular adenine nucleotide hydrolysis and blood platelet aggregation in patients diagnosed for cervical intraepithelial neoplasia in different stages as well as uterine invasive cancer.
Patients and methods |
NTPDase, E-NPP, 5′-nucleotidase, total ADA and its isoforms (ADA1 and ADA2), as well as the platelet aggregation from patients with different stages of cervical intraepithelial neoplasia (NICs I, NIC II, NIC III) and uterine invasive cancer were verified.
Results |
Neither ATP hydrolysis nor E-NPP activity was changed by the neoplasia stage. On the other hand, ADP and AMP hydrolysis as well as ADA activity were enhanced in NIC I group. AMP hydrolysis was also increased in the cancer group. ADA 1 was the ADA isoform found in platelets from both control and patient groups.
Conclusion |
Our results showed for the first time that NTPDase, 5′-nucleotidase, E-NPP and ADA are not sensible regarding the grade of neoplasia development, since no significant difference was found between the groups studied. Only ADP hydrolysis and ADA activity showed a significant enhancement in NIC I group related to the other stages possibly as a result of the beginning of the neoplasic transformation. This increase could be reflecting a body’s reaction against the probable high adenosine levels. We propose for the first time that the ADA isoform present in platelets is ADA 1.
Le texte complet de cet article est disponible en PDF.Keywords : Adenine nucleotides, Uterine cancer, Thrombosis
Plan
Vol 66 - N° 1
P. 6-11 - février 2012 Retour au numéro
Article précédent
- Trichostatin A reduced phospholipase C gamma-1 transcript and protein contents in MCF-7 breast cancer cells
- H. Drzewiecka, P.P. Jagodzinski
- Sorafenib sensitizes human colorectal carcinoma to radiation via suppression of NF-κB expression in vitro and in vivo
- Yu-Cheng Kuo, Wei-Chan Lin, I-Tsang Chiang, Ya-Fang Chang, Chia-Wen Chen, Shih-Hao Su, Chuan-Lin Chen, Jeng-Jong Hwang
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’achat d’article à l’unité est indisponible à l’heure actuelle.
Déjà abonné à cette revue ?