Chronic Q fever: Review of the literature and a proposal of new diagnostic criteria - 07/02/12

Doi : 10.1016/j.jinf.2011.12.014

M.C.A. Wegdam-Blans ^a,^⁎,^{^{i
Both authors contributed equally.}} , L.M. Kampschreur ^b,^{^{i
Both authors contributed equally.}}, C.E. Delsing ^c, C.P. Bleeker-Rovers ^c, T. Sprong ^d, M.E.E. van Kasteren ^e, D.W. Notermans ^f, N.H.M. Renders ^g, H.A. Bijlmer ^f, P.J. Lestrade ^h, M.P.G. Koopmans ^f, M.H. Nabuurs-Franssen ^d, J.J. Oosterheert ^b
The Dutch Q fever Consensus Group^{^j}
See Members of the Dutch Q fever Consensus Group Section.
^a Department of Medical Microbiology, Laboratory for Pathology and Medical Microbiology (PAMM), Veldhoven, The Netherlands
^b Division of Medicine, Department of Internal Medicine and Infectious Diseases, University Medical Center, Utrecht, The Netherlands
^c Department of Internal Medicine, Division of Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
^d Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Ziekenhuis, Nijmegen, The Netherlands
^e Department of Internal Medicine, St. Elisabeth Hospital, Tilburg, The Netherlands
^f Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
^g Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital’s, Hertogenbosch, The Netherlands
^h Department of Internal Medicine, Jeroen Bosch Hospital’s, Hertogenbosch, The Netherlands

Corresponding author. Tel.:+31 408888100; fax: +31 408888182.

Summary

A review was performed to determine clinical aspects and diagnostic tools for chronic Q fever. We present a Dutch guideline based on literature and clinical experience with chronic Q fever patients in The Netherlands so far. In this guideline diagnosis is categorized as proven, possible or probable chronic infection based on serology, PCR, clinical symptoms, risk factors and diagnostic imaging.

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Keywords : Chronic Q fever, Coxiella burnetii, Endocarditis, Vascular infections