Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC - 02/02/12

Doi : 10.1016/S1470-2045(12)70040-2

Augusto Caraceni, ProfMD ^a,^c,^⁎,^{^{†
These authors contributed equally}} , Geoffrey Hanks, ProfDSc (Med) ^b,^{^{†
These authors contributed equally}}, Stein Kaasa, ProfMD ^c,^f,^{^{†
These authors contributed equally}}, Michael I Bennett, ProfMD ^h, Cinzia Brunelli, ScD ^a, Nathan Cherny, ProfMD ⁱ, Ola Dale, ProfMD ^d, Franco De Conno, MD ^j, Marie Fallon, ProfMD ^k, Magdi Hanna, FCA ^l, Dagny Faksvåg Haugen, PhD ^e,^m, Gitte Juhl, MD ⁿ, Samuel King, MRCP ^b, Pål Klepstad, MD ^d,^g, Eivor A Laugsand, MD ^c, Marco Maltoni, MD ^o, Sebastiano Mercadante, MD ^p,^q, Maria Nabal, MD ^r, Alessandra Pigni, MD ^a, Lukas Radbruch, ProfMD ^s, Colette Reid, MD ^b, Per Sjogren, ProfMD ^t, Patrick C Stone, MD ^u, Davide Tassinari, MD ^v, Giovambattista Zeppetella, FRCP ^w

for the European Palliative Care Research Collaborative (EPCRC)

on behalf of the European Association for Palliative Care (EAPC)

^a Palliative Care, Pain Therapy and Rehabilitation, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

^b Department of Palliative Medicine, Bristol Haematology & Oncology Centre, University of Bristol, Bristol, UK

^c Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

^d European Palliative Care Research Centre (PRC), Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

^e Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

^f Department of Oncology, St Olav University Hospital, Trondheim, Norway

^g Department of Anesthesiology and Emergency Medicine, St Olav University Hospital, Trondheim, Norway

^h Leeds Institute of Health Sciences, University of Leeds, Leeds, UK

ⁱ Department of Oncology, Shaare Zedek Medical Centre, Jerusalem, Israel

^j European Association of Palliative Care, Milan, Italy

^k St Columbia’s Hospice, University of Edinburgh, Edinburgh, UK

^l Analgesics and Pain Research Unit, King’s College London, London, UK

^m Regional Centre of Excellence for Palliative Care, Western Norway, Haukeland University Hospital, Bergen, Norway

ⁿ Palliative Care Unit, Department of Anaesthesia, Copenhagen University Hospital Herlev, Herlev, Denmark

^o Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy

^p Anaesthesia and Intensive Care Unit, Pain Relief and Palliative Care Unit, La Maddalena Cancer Centre, Palermo

^q Department of Anaesthesia and Intensive Care, Palliative Medicine, University of Palermo, Palermo, Italy

^r Palliative Care Supportive Team, Hospital Universitario Arnau de Vilanova, Lleida, Spain

^s Department of Palliative Medicine, University Hospital Bonn, Bonn, Germany

^t Multidisciplinary Pain Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

^u Population Health Sciences and Education, St George’s University of London, London, UK

^v Supportive and Palliative Care Unit, Department of Oncology, City Hospital, Rimini, Italy

^w Patient Services, St Clare Hospice, Hastingwood, UK

^* Correspondence to: Prof Augusto Caraceni, Palliative Care, Pain Therapy, and Rehabilitation Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, via Venezian 1, 20133 Milan, Italy

Summary

Here we provide the updated version of the guidelines of the European Association for Palliative Care (EAPC) on the use of opioids for the treatment of cancer pain. The update was undertaken by the European Palliative Care Research Collaborative. Previous EAPC guidelines were reviewed and compared with other currently available guidelines, and consensus recommendations were created by formal international expert panel. The content of the guidelines was defined according to several topics, each of which was assigned to collaborators who developed systematic literature reviews with a common methodology. The recommendations were developed by a writing committee that combined the evidence derived from the systematic reviews with the panellists’ evaluations in a co-authored process, and were endorsed by the EAPC Board of Directors. The guidelines are presented as a list of 16 evidence-based recommendations developed according to the Grading of Recommendations Assessment, Development and Evaluation system.

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Vol 13 - N° 2

P. e58-e68 - février 2012 Retour au numéro

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Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC - 02/02/12

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