The triple therapy has brought about a genuine revolution in the care of patients with chronic hepatitis C virus infection, although achieving a high cure rate requires adding disciplines beyond the attending physician when confronted by a motivated patient. The treatment is complex because of the many parameters involved (such as fibrosis score, patient’s history of previous antiviral treatment and viral kinetics during treatment). A working knowledge of drug interactions and contraindications for drugs other than antiviral therapy is required, as well as meticulous follow-up.