Use of Skeletal Muscle MRI in Diagnosis and Monitoring Disease Progression in Duchenne Muscular Dystrophy - 11/01/12

Doi : 10.1016/j.pmr.2011.11.004

Erika L. Finanger, MD, MS ^a,^b,^c,^⁎ , Barry Russman, MD ^a,^b,^c, Sean C. Forbes, PhD ^d, William D. Rooney, PhD ^e, Glenn A. Walter, PhD ^f, Krista Vandenborne, PT, PhD ^d
^a Department of Pediatrics, Oregon Health and Science University, 707 SW Gaines Street, CDRC-P, Portland, OR 97239, USA
^b Department of Neurology, Oregon Health and Science University, 707 SW Gaines Street, CDRC-P, Portland, OR 97239, USA
^c Shriners Hospital for Children Portland, 3101 SW Sam Jackson Park Road, Portland, OR 97239, USA
^d Department of Physical Therapy, University of Florida, Gainesville, FL 32610, USA
^e Advanced Imaging Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
^f Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL 32610, USA

Corresponding author. Oregon Health and Science University, Pediatric Neurology, 707 SW Gaines Street, CDRC-P, Portland, OR 97239.

Résumé

Studies have shown promise in using various approaches of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy to evaluate skeletal muscle involvement in Duchenne muscular dystrophy. However, these studies have mainly been performed using a cross-sectional design, and the correlation of these MRI changes with disease progression and disease severity has not been fully elucidated. Overall, skeletal muscle MRI is a powerful and sensitive technique in the evaluation of muscle disease, and its use as a biomarker for disease progression or therapeutic response in clinical trials deserves further study.

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Keywords : MRI, Duchenne muscular dystrophy, Skeletal muscle