Does air pollution increase the effect of aeroallergens on hospitalization for asthma? - 24/12/11
, Frances Coates, MLT c
Corresponding author: Robert E. Dales, MD, MSc, Ottawa Hospital (General Campus), 501 Smyth Rd, Box 211, Ottawa, Ontario K1H 8L6, Canada.Abstract |
Background |
Clinical experiments demonstrate that the asthmatic response to an aeroallergen can be enhanced by prior exposure to an air pollutant.
Objective |
We sought to compare the effects of ambient aeroallergens on hospitalization for asthma between high and low air pollution days in 11 large Canadian cities.
Methods |
Daily time-series analysis was used, and results were adjusted for day of the week, temperature, barometric pressure, and relative humidity.
Results |
The relative risk of admission for an interquartile increase in tree pollen levels was 1.124 (95% CI, 1.101-1.147) on days of lower values of fine particulate matter with a median aerodynamic diameter less than or equal to 2.5 μm (PM2.5) compared with 1.179 (95% CI, 1.149-1.21) on days of higher PM2.5 values. Significant (P ≤ .05) differences in the relative risks of admission between lower versus higher values of particulate matter with a median aerodynamic diameter less than or equal to 10 μm in diameter were 1.149 (95% CI, 1.118-1.181) versus 1.210 (95% CI, 1.161-1.261) for ascomycetes, 1.112 (95% CI, 1.085-1.14) versus 1.302 (95% CI, 1.242-1.364) for basidiomycetes, 1.159 (95% CI, 1.125-1.195) versus 1.149 (95% CI, 1.129-1.169) for deuteromycetes, and 1.061 (95% CI, 1.016-1.107) versus 1.117 (95% CI, 1.092-1.143) for weeds.
Conclusion |
We identified an association between aeroallergens and hospitalizations for asthma, which was enhanced on days of higher air pollution. Minimizing exposure to air pollution might reduce allergic exacerbations of asthma.
Le texte complet de cet article est disponible en PDF.Key words : Asthma, hospitalization, allergens, air pollution, epidemiology
Abbreviations used : PM10, PM2.5
Plan
| Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest. |
Vol 129 - N° 1
P. 228-231 - janvier 2012 Retour au numéro
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