Effects of air pollutants on innate immunity: The role of Toll-like receptors and nucleotide-binding oligomerization domain–like receptors - 24/12/11
Corresponding author: Ilona Jaspers, PhD, 104 Mason Farm Rd, Chapel Hill, NC 27599-7310.Abstract |
Interactions between exposure to ambient air pollutants and respiratory pathogens have been shown to modify respiratory immune responses. Emerging data suggest key roles for Toll-like receptor (TLR) and nucleotide-binding oligomerization domain–like receptor (NLR) signaling in pathogen-induced immune responses. Similarly, immune responses elicited by exposure to air pollutants are mediated by specific TLR- and NLR-dependent mechanisms. This review article will summarize current knowledge about how air pollutants modify TLR- and NLR-dependent signaling and host defense responses in the lung.
Le texte complet de cet article est disponible en PDF.Key words : Toll-like receptor, NOD-like receptor, pattern recognition receptor, inflammasome, cigarette smoke, particulate matter, ozone, diesel exhaust, nanoparticles, air pollutant, innate immunity, host defense, pathogen-associated molecular pattern, danger-associated molecular pattern, lung, airway
Abbreviations used : BAL, COPD, CS, CSC, CSE, DAMP, DC, DEP, HA, Hsp70, IP-10, IRF, MyD88, NF-κB, NLR, NLRP, NO, NOD, PAMP, pDC, PM, PRR, ROS, TiO2, TIR, TLR, TRIF
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| Series editors: Joshua A. Boyce, MD, Fred Finkelman, MD, William T. Shearer, MD, PhD, and Donata Vercelli, MD |
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| The article has been reviewed by the National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency and approved for publication. Approval does not signify that the contents necessarily reflect the views and the policies of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. |
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| Terms in boldface and italics are defined in the glossary on page 15. |
Vol 129 - N° 1
P. 14-24 - janvier 2012 Retour au numéro
Article précédent
- Respiratory health effects of air pollution: Update on biomass smoke and traffic pollution
- Effects of air pollutants on innate immunity: The role of Toll-like receptors and nucleotide-binding oligomerization domain–like receptors
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