Fatal hemophagocytic syndrome in a patient with a previously well-controlled asymptomatic HIV infection after EBV reactivation - 23/12/11
, Siegbert Rieg a, b, Nils Venhoff a, b, Vanessa Wennekes b, Annette Schmitt-Graeff c, Dirk Wagner a, b, Winfried V. Kern a, b
Corresponding author. University Hospital Freiburg, Department of Rheumatology and Clinical Immunology, Centre of Chronic Immunodeficiency – CCI, Hugstetter Strasse 55, 79106 Freiburg, Germany. Tel.: +49 761 270 36950; fax: +49 761 270 35310.Summary |
We present a rare case of hemophagocytic lymphohistiocytosis (HLH) in a 70 year-old male patient with previously well-controlled HIV infection. We could confirm HLH in different organs post mortem. Since the diagnosis of HLH was delayed, the patient died despite initiation of chemotherapy. As cause for HLH, an EBV reactivation could be confirmed.
In HIV infection, HLH may be the first HIV manifestation, often triggered by an opportunistic infection or immune reconstitution syndrome, but it is uncommon in the state of a well-controlled or aviremic HIV infection.
Le texte complet de cet article est disponible en PDF.Keywords : Hemophagocytic lymphohistiocytosis, Hemophagocytosis, HIV, EBV, Bone marrow
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Vol 64 - N° 1
P. 110-112 - janvier 2012 Retour au numéro
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