Development of Hypertension in Adolescents with Pre-Hypertension - 08/12/11
, Alisa A. Acosta, MD, MPH 2, Timothy Poffenbarger 3, Ronald J. Portman, MD 4, Joshua Samuels, MD, MPH 3
Reprint requests: Karen M. Redwine, MD, MPH, Division of Pediatric Nephrology, University of Arkansas for Medical Sciences, 1 Children’s Way, Slot 512-14, Little Rock, AR 72202.Abstract |
Objective |
To evaluate the risk for developing incident hypertension (HTN) in adolescents with pre-hypertension.
Study design |
A secondary analysis of students participating in multiple school-based blood pressure (BP) screens from 2000 to 2007 was completed. At each screen, height, weight, and 2 to 4 BPs were measured on as many as 3 occasions when BP remained ≥95th percentile. Students with confirmed HTN at their initial screen were excluded, and incident HTN was defined as having a BP ≥95th percentile at all 3 visits of a later screen. Incidence rates (IR) and hazard ratios (HR) were calculated by using Cox Proportional models.
Results |
Of 1006 students, HTN developed in 11 (IR 0.5%/year) in a mean of 2.1 years of observation. IRs were higher in “at-risk” students (pre-hypertensive or hypertensive with follow-up BP <95th percentile), 1.4%/year (HR, 4.89; 1.48-16.19) and students with a BP ≥90th percentile at 3 baseline visits, 6.6%/year HR 24.33 (5.68-104.29)]. Although not significant, students with pre-hypertension by the 2004 Task Force definition also had an increased IR of 1.1%/year (HR, 2.98; 0.77-11.56)].
Conclusion |
Elevated BP increases the risk for the development of HTN during adolescence. Effective strategies for preventing HTN in at-risk adolescents are needed.
Le texte complet de cet article est disponible en PDF.Mots-clés : BP, BMI, HR, HTN, IR
Plan
| Portions of the screening program were funded by unrestricted grants from AstraZeneca, Daiichi Sankyo, and King Pharmaceuticals. K.R. received salary support in part by an unrestricted grant from the Arkansas Children’s Hospital Research Institute and the Arkansas Bioscienses Institute, the major research component of the Tobacco Settlement Proceeds Act of 2000. These companies and institutions had no input into the design, content, or interpretation of the study or the development of this manuscript. The other authors declare no conflicts of interest. |
Vol 160 - N° 1
P. 98-103 - janvier 2012 Retour au numéro
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