Development of Cystic Periventricular Leukomalacia in Newborn Infants after Rotavirus Infection - 08/12/11

Doi : 10.1016/j.jpeds.2011.08.053

Malgorzata A. Verboon-Maciolek, MD, PhD ¹, Anita C. Truttmann, MD, PhD ³, Floris Groenendaal, MD, PhD ¹, Jon Skranes, MD, PhD ⁴, Henrik Døllner, MD, PhD ⁴, Rod W. Hunt, BMBS, PhD ⁵, Michael Hayman, MD, PhD ⁵, Rob J. Dippersloot, MD, PhD ⁶, Anton M. van Loon, MD, PhD ², Linda S. de Vries, MD, PhD ^1,^⁎
¹ Department of Neonatology, University Medical Center, Utrecht, The Netherlands
² Department of Virology, University Medical Center, Utrecht, The Netherlands
³ Neonatology Unit, Department of Pediatrics and Pediatric Surgery, University Hospital Center and University of Lausanne, Lausanne, Switzerland
⁴ Department of Pediatrics, St Olav University Hospital and Department of Laboratory Medicine, Children’s and Women’s Health, Norwegian University of Science and Technology, Trondheim, Norway
⁵ Departments of Neonatal Medicine and Neurology, Royal Children’s Hospital, Murdoch Children’s Research Institute, University of Melbourne, Melbourne, Australia
⁶ Department of Medical Microbiology and Immunology, Diakonessen Hospital, Utrecht, The Netherlands

Reprint requests: Linda S. de Vries, MD, PhD, Department of Neonatology, KE 04.123.1, University Medical Center, Lundlaan 6, 3584 EA Utrecht, The Netherlands.

Abstract

We describe 5 preterm and 3 term infants who presented with seizures during rotavirus infection within 6 weeks after birth. Six of these infants developed late-onset cystic periventricular leukomalacia. Four of the preterm infants had neurodevelopmental delay, and 4 (near) term infants had normal early outcome.

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Mots-clés : c-PVL, CSF, cUS, MRI, PCR