Short-Term Zinc Supplementation with Dispersible Tablets or Zinc Sulfate Solution Yields Similar Positive Effects on Plasma Zinc Concentration of Young Children in Burkina Faso: A Randomized Controlled Trial - 08/12/11
Abstract |
Objective |
To assess zinc absorption from dispersible tablets by investigating the effects of short-term zinc supplementation, provided either as zinc (Zn) sulfate dispersible tablets or solution, on changes in plasma Zn concentration in young children.
Study design |
We conducted a randomized, partially-masked, placebo-controlled trial in 451 children 6 to 23 months of age in Burkina Faso, randomly assigned to receive a dispersible tablet containing 5 mg Zn, a Zn solution containing 5 mg Zn/5 mL, or a placebo solution, daily for 3 weeks. The main outcome measure was change in plasma zinc concentration after supplementation compared with baseline.
Results |
The mean plus or minus SD change in plasma Zn concentration (μg/dL) was significantly greater in both Zn supplemented groups (tablets: 16.9±13.1μg/dL, liquid: 16.6±14.2 μg/dL), compared with the placebo group (0.2±10.9 μg/dL; P<.001, ANOVA). In both Zn supplemented groups, but not in the placebo group, change in plasma Zn concentration was progressively less with increasing age in months (−0.79 μg/dL/mo and −1.15 μg/dL/mo, respectively; P<.001); this effect did not differ in the Zn supplemented groups (P=.18).
Conclusions |
Short-term supplementation results in a large increase in plasma Zn concentration, regardless of whether the additional Zn is provided as a dispersible tablet or solution.
Le texte complet de cet article est disponible en PDF.Mots-clés : AGP, CRP, Cu, IZiNCG, LAZ, WAZ, WLZ, Zn, ZnLiq, ZnTab
Plan
| Funded by a grant from Nutriset, SAS, Malauney, France, which had no influence on the study design, collection, analysis, interpretation of data, writing of the report, and the decision to submit the article for publication. The authors declare no conflicts of interest. |
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| Registered at clinicaltrials.gov: NCT00944853. |
Vol 160 - N° 1
P. 129 - janvier 2012 Retour au numéro
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